ChloroquineV1, Main, Exploration, bibRecord, 003473

Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse

Identifieur interne : 003473 ( Main/Exploration ); précédent : 003472; suivant : 003474

Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse

Auteurs : John M. Young [États-Unis] ; Patrick J. Maloney [États-Unis] ; Shizu N. Jubb [États-Unis] ; Jeffrey S. Clark [États-Unis]

Source :

Prostaglandins [ 0090-6980 ] ; 1985.

RBID : ISTEX:7B17991467E77F02DA660C0C5F027CFD5E9645B3

English descriptors

Teeft :
- Allergy, Anaphylaxis, Antagonist, Arachidonic, Blocker, Cyclooxygenase, Dapsone, Diphenyldisulfide, Dos, Hilltop, Iipoxygenase, Inhibitor, Leukocyte, Leukotriene, Lipoxygenase, Mediator, Mouse, October, Pathway, Pharmac, Pharmacologic, Phenidone, Platelet, Prostaglandin, Prostaglandins table, Swiss webster.

Abstract

Abstract: Although the platelets the mouse are refractory to the direct effects of platelet-activating-factor (PAF0, tail vein injection of 10–150 μg/kg PAF produces lethal anaphylatic shook. Sensitivity varies with strain and source: Swiss Webster mice show a range of sensitivity and DBA/2 (complement C5-deficient) mice are very resistant. At lethal doses within 15–45 min. Dexamethasone administered at least 1.5 hr prior consistently protects, whereas the cyclooxygenase inhibitors do not. Antihistamines, adrenergic antagonists, and methysergide have no effect, but cyproheptidine is partially protective at near lethal doses. Calcium entry blockers and calcium chelators, tetracyline and chlortetracycline are partially protective at very high doses consistent with non-specific effects on calcium dependent processes. The arachidonic acid lipoxygenase inhibitors BW755c, phenidone, nordihydroguai aretic acid and diphenyl disulfide provide nearly complete protection after oral administration of 50–200 mg/kg. Phosphodiesterase inhibitors and dapsone are also effectively orally. The luekotriene antagonist FPL55712 administered intraperitoneally (10 mg/kg) 5 min. prior to PAF challenge provides almost complete protection. PAF-induced mortality in the mouse represents a small animal model of systematic anaphylaxis particularly useful for the systematic testing of arachidonic acid lipoxygenase inhibitors and leukotriene antagonists.

Url:

https://api.istex.fr/ark:/67375/6H6-LN1C3140-M/fulltext.pdf

DOI: 10.1016/0090-6980(85)90018-8

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Although the platelets the mouse are refractory to the direct effects of platelet-activating-factor (PAF0, tail vein injection of 10–150 μg/kg PAF produces lethal anaphylatic shook. Sensitivity varies with strain and source: Swiss Webster mice show a range of sensitivity and DBA/2 (complement C5-deficient) mice are very resistant. At lethal doses within 15–45 min. Dexamethasone administered at least 1.5 hr prior consistently protects, whereas the cyclooxygenase inhibitors do not. Antihistamines, adrenergic antagonists, and methysergide have no effect, but cyproheptidine is partially protective at near lethal doses. Calcium entry blockers and calcium chelators, tetracyline and chlortetracycline are partially protective at very high doses consistent with non-specific effects on calcium dependent processes. The arachidonic acid lipoxygenase inhibitors BW755c, phenidone, nordihydroguai aretic acid and diphenyl disulfide provide nearly complete protection after oral administration of 50–200 mg/kg. Phosphodiesterase inhibitors and dapsone are also effectively orally. The luekotriene antagonist FPL55712 administered intraperitoneally (10 mg/kg) 5 min. prior to PAF challenge provides almost complete protection. PAF-induced mortality in the mouse represents a small animal model of systematic anaphylaxis particularly useful for the systematic testing of arachidonic acid lipoxygenase inhibitors and leukotriene antagonists.</div>
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Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse

Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri